Phenotypes associated with this allele

• Allele Symbol: Arpin^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:8187429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arpin^em1Cya/Arpin^em1Cya	involves: C57BL/6JCya	MGI:8187430

Genotype
MGI:8187430

hm1

• Allelic Composition: Arpin^em1Cya/Arpin^em1Cya
• Genetic Background: involves: C57BL/6JCya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal venule morphology ( J:365041 )

• post-capillary venules of cremaster muscles display VE-Cadherin internalization leading to zipper-like junction structure

pulmonary alveolar hemorrhage ( J:365041 )

• signs of hemorrhage and microhemorrhage

increased vascular permeability ( J:365041 )

• permeability in the lung is increased about 2-fold compared to wild-type controls

• vascular permeability is also increased in the skin and histamine stimulation further increases permeability

• treatment with a ROCK1/2 inhibitor reverts permeability to basal levels seen in wild-type mice

respiratory system

pulmonary alveolar hemorrhage ( J:365041 )

• signs of hemorrhage and microhemorrhage

abnormal lung morphology ( J:365041 )

• presence of lymphocytes and macrophages in the lungs

• however, the number of leukocytes in the peripheral blood is similar to controls

• elevated levels of F-actin

pulmonary edema ( J:365041 )

• presence of interalveolar edema

abnormal pulmonary alveolar system morphology ( J:365041 )

• reduced volume of alveolar space

homeostasis/metabolism

pulmonary edema ( J:365041 )

• presence of interalveolar edema