Arpin^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arpin^em1Cya
• Name: actin-related protein 2/3 complex inhibitor; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:8187429
• Gene: Arpin Location: Chr7:79575107-79585012 bp, - strand Genetic Position: Chr7, 45.27 cM, cytoband D2
• Alliance: Arpin^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs (CTATGCAGCAGGGTAGCGCCAGG and CGCACAGTGATAGTCGGAGCCGG) targeting exon 3 created a null allele. Western blot analysis confirmed the absence of expression in homozygous mice. (J:365041)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arpin Mutation: 23 strains or lines available

References

• Original: J:365041 Montoya-Garcia A, et al., Arpin deficiency increases actomyosin contractility and vascular permeability. Elife. 2024 Sep 19;12
• All: 1 reference(s)