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Arpinem1Cya
Endonuclease-mediated Allele Detail
Summary
Symbol: Arpinem1Cya
Name: actin-related protein 2/3 complex inhibitor; endonuclease-mediated mutation 1, Cyagen Biosciences
MGI ID: MGI:8187429
Gene: Arpin  Location: Chr7:79575107-79585012 bp, - strand  Genetic Position: Chr7, 45.27 cM, cytoband D2
Alliance: Arpinem1Cya page
Mutation
origin
Strain of Origin:  C57BL/6JCya
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/cas9 mediated recombination using guide RNAs (CTATGCAGCAGGGTAGCGCCAGG and CGCACAGTGATAGTCGGAGCCGG) targeting exon 3 created a null allele. Western blot analysis confirmed the absence of expression in homozygous mice. (J:365041)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arpin Mutation:  23 strains or lines available
References
Original:  J:365041 Montoya-Garcia A, et al., Arpin deficiency increases actomyosin contractility and vascular permeability. Elife. 2024 Sep 19;12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory