Phenotypes associated with this allele

• Allele Symbol: Mblac1^em1Rbl
• Allele Name: endonuclease-mediated mutation 1, Randy D Blakely
• Allele ID: MGI:8186384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mblac1^em1Rbl/Mblac1^em1Rbl	C57BL/6J-Mblac1^em1Rbl	MGI:8276967

Genotype
MGI:8276967

hm1

• Allelic Composition: Mblac1^em1Rbl/Mblac1^em1Rbl
• Genetic Background: C57BL/6J-Mblac1^em1Rbl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal metabolism ( J:344443 )

• global untargeted serum metabolomic analyses highlighted alterations in multiple metabolic pathways; MetaboAnalyst 3.0 and KEGG pathway analysis identified several impacted pathways linked to neuroprotective, oxidative stress reducing pathways; an independent validation study confirmed that top affected metabolic pathways include primary bile acid biosynthesis and linoleate metabolism

• however, homozygotes are viable, produce offspring at normal Mendelian ratios, and show no overt physical or behavioral abnormalities