Phenotypes associated with this allele

• Allele Symbol: Trim47^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech
• Allele ID: MGI:8172182
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trim47^em1Gpt/Trim47^em1Gpt Tg(Cdh5-cre/ERT2)1Rha/0	involves: C57BL/6JGpt	MGI:8354338

Genotype
MGI:8354338

cn1

• Allelic Composition: Trim47^em1Gpt/Trim47^em1Gpt; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal long-term spatial reference memory ( J:385512 )

• at 3-5 months of age, tamoxifen-treated male mice show impaired performance in the Morris water maze assay, akin to that observed in mice homozygous for the Trim47^em1(IMPC)Bay allele

abnormal short-term spatial reference memory ( J:385512 )

• at 3-5 months of age, tamoxifen-treated male mice show impaired performance in the Y-maze assay, akin to that observed in mice homozygous for the Trim47^em1(IMPC)Bay allele

nervous system

impaired blood-brain barrier function ( J:385512 )

• tamoxifen-treated adult mice show impaired blood-brain barrier (BBB) function, as indicated by an increased BBB permeability index following 3 kDa dextran injection and reduced expression of key adherens and tight junction components in brain endothelial cells (ECs)

cellular

oxidative stress ( J:385512 )

• qPCR analysis indicated downregulation of critical Nrf2 target genes, including Hmox1 and Slc7a11, in brain ECs

cardiovascular system

impaired blood-brain barrier function ( J:385512 )

• tamoxifen-treated adult mice show impaired blood-brain barrier (BBB) function, as indicated by an increased BBB permeability index following 3 kDa dextran injection and reduced expression of key adherens and tight junction components in brain endothelial cells (ECs)

growth/size/body

growth/size/body region phenotype ( J:385512 )

N • at 3-5 months of age, tamoxifen-treated male mice show no significant differences in body weight relative to control littermates

renal/urinary system

renal/urinary system phenotype ( J:385512 )

N • tamoxifen-treated adult mice show normal glomerular filtration barrier function in the kidney