Phenotypes associated with this allele

• Allele Symbol: Otud3^em2Yxy
• Allele Name: endonuclease-mediated mutation 2, Yuxin Yin
• Allele ID: MGI:8169786
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otud3^em2Yxy/Otud3^em2Yxy	C57BL/6-Otud3^em2Yxy	MGI:8345743

Genotype
MGI:8345743

hm1

• Allelic Composition: Otud3^em2Yxy/Otud3^em2Yxy
• Genetic Background: C57BL/6-Otud3^em2Yxy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased abdominal adipose tissue amount ( J:351461 )

• increased proportion of retroperitoneal fat after being fed HFD for 10 weeks from age 8 weeks

• normal proportion of retroperitoneal fat after being fed standard chow for 10 weeks from age 8 weeks

increased body fat mass ( J:351461 )

• increased fat accumulation in WAT, BAT, skeletal muscle and liver after being fed HFD for 10 weeks from age 8 weeks

• increased fat droplet accumulation in liver and skeletal muscle after being fed standard chow for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased brown adipose tissue mass ( J:351461 )

• after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased white adipose tissue mass ( J:351461 )

• after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

behavior/neurological

behavior/neurological phenotype ( J:351461 )

N • normal food intake on HFD or standard chow

N • normal physical activity on HFD or standard chow

cellular

decreased cellular ATP level ( J:351461 )

• in WAT after being fed HFD for 10 weeks from age 8 weeks

decreased mitochondria enzyme/coenzyme activity ( J:351461 )

• lower respiration chain complex activities (except complex II) in mitochondria from WAT, BAT, skeletal muscle and liver after being fed HFD for 10 weeks from age 8 weeks

abnormal oxidative phosphorylation ( J:351461 )

• lower levels of OXPHOS in WAT and skeletal muscle

embryo

embryo phenotype ( J:351461 )

N • mice born at expected mendelian ratios

growth/size/body

increased body fat mass ( J:351461 )

• increased fat accumulation in WAT, BAT, skeletal muscle and liver after being fed HFD for 10 weeks from age 8 weeks

• increased fat droplet accumulation in liver and skeletal muscle after being fed standard chow for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased susceptibility to diet-induced obesity ( J:351461 )

• more weight gain after being fed HFD for 10 weeks from age 8 weeks

• normal weight after being fed standard chow for 10 weeks from age 8 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:351461 )

• normal respiratory quotient on HFD or standard chow

• normal body surface temperature on HFD or standard chow

decreased cellular ATP level ( J:351461 )

• in WAT after being fed HFD for 10 weeks from age 8 weeks

decreased mitochondria enzyme/coenzyme activity ( J:351461 )

• lower respiration chain complex activities (except complex II) in mitochondria from WAT, BAT, skeletal muscle and liver after being fed HFD for 10 weeks from age 8 weeks

increased susceptibility to diet-induced obesity ( J:351461 )

• more weight gain after being fed HFD for 10 weeks from age 8 weeks

• normal weight after being fed standard chow for 10 weeks from age 8 weeks

increased circulating insulin level ( J:351461 )

• higher fasting insulin levels after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased circulating cholesterol level ( J:351461 )

• after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased circulating free fatty acids level ( J:351461 )

• after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

increased circulating triglyceride level ( J:351461 )

• after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

impaired glucose tolerance ( J:351461 )

• increased glucose intolerance after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

insulin resistance ( J:351461 )

• higher fasting serum insulin levels after being fed HFD for 10 weeks from age 8 weeks

• normal after being fed standard chow for 10 weeks from age 8 weeks

liver/biliary system

increased susceptibility to diet-induced hepatic steatosis ( J:351461 )

• normal after being fed standard chow for 10 weeks from age 8 weeks

mortality/aging

mortality/aging ( J:351461 )

• mice born at expected mendelian ratios