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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prmt9em1Sqiu
endonuclease-mediated mutation 1, Shenfeng Qiu
MGI:8166513
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Prmt9em1Sqiu/Prmt9em1Sqiu
Emx1tm1(cre)Krj/Emx1+
B6.Cg-Emx1tm1(cre)Krj Prmt9em1Sqiu MGI:8166762


Genotype
MGI:8166762
cn1
Allelic
Composition
Prmt9em1Sqiu/Prmt9em1Sqiu
Emx1tm1(cre)Krj/Emx1+
Genetic
Background
B6.Cg-Emx1tm1(cre)Krj Prmt9em1Sqiu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (29 available)
Prmt9em1Sqiu mutation (0 available); any Prmt9 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show less conditioned contextual freezing during the test phase of the fear conditioning test
• however, no differences in the open field or elevated plus maze are seen indicating normal basal locomotor activity and levels of anxiety or reaction to novelty
• in the fear conditioning test, mice are slower in associating an auditory tone (conditioned stimulus) with a foot shock (unconditioned stimulus)
• 10-14-week-old mice show slower spatial memory acquisition during the Morris water maze training phase
• 10-14-week-old mice spend less time in the target quadrant during the Morris water maze probe trial
• in the reverse learning test, during which the platform is moved to a new location, mice exhibit slower learning of the new platform location, indicating impaired cognitive flexibility

nervous system
• hippocampal neurons show impaired excitatory synapse maturation
• hippocampus CA1 neurons show a reduction in spine density and head volume, indicating defective synapse development
• however, dendritic arborization is not affected
• hippocampus neurons show impaired excitatory synapse development
• primary embryonic hippocampus neurons show a reduced density of PSD95+, GluN1+, and GluA1+ puncta and decreased colocalization of pre-/post-synaptic and AMPA/NMDA markers, indicating reduction in the number of functional excitatory synapses
• CA1 neurons from young adults (12-14 weeks old) show reduced spontaneous miniature excitatory postsynaptic currents (mEPSCs) amplitude, with more mEPSCs amplitudes clustered to the lower amplitude bins
• mEPSC frequency is decreased in CA1 neurons
• overall reduction in postsynaptic fEPSP response to presynaptic inputs in CA1 responses, while paired pulse ratio responses across various inter-stimulus intervals are not altered
• decrease in AMPA/NMDA receptor current ratio in CA1 neurons
• reduction of long-term potentiation (LTP) from CA1 region
• reduction of long-term depression (LTD) from CA1 region





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/22/2025
MGI 6.24
The Jackson Laboratory