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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tent5bem3Adki
endonuclease-mediated mutation 3, Andrzej Dziembowski
MGI:8164233
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tent5bem3Adki/Tent5bem3Adki involves: C57BL/6JTar * CBA/WTar MGI:8164383
ht2
 		Tent5bem3Adki/Tent5b+ involves: C57BL/6JTar * CBA/WTar MGI:8164389


Genotype
MGI:8164383
hm1
Allelic
Composition		 Tent5bem3Adki/Tent5bem3Adki
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5bem3Adki mutation (0 available); any Tent5b mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:360869 )
• oocytes remain alive in the ovaries and progress further in meiosis through germinal vesicle to the second metaphase (MII) stage but show abnormalities in spindle and chromatin organization in metaphase II oocytes

cellular
abnormal female meiosis ( J:360869 )
• oocytes remain alive in the ovaries and progress further in meiosis through germinal vesicle to the second metaphase (MII) stage but show abnormalities in spindle and chromatin organization in metaphase II oocytes




Genotype
MGI:8164389
ht2
Allelic
Composition		 Tent5bem3Adki/Tent5b+
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5bem3Adki mutation (0 available); any Tent5b mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:360869 )
• most oocytes have either one or several chromosomes separated from the main group of chromosomes
• oocytes remain alive in the ovaries and progress further in meiosis through germinal vesicle to the second metaphase (MII) stage, however approximately 25% of MII oocytes exhibit chromosomal segregation and chromatin organization abnormalities, with meiotic spindle disruption, scattered chromosomes, parthenogenic activation, and large, seemingly empty or fluid-filled follicles within the cytosol
parthenogenesis ( J:360869 )
• some MII oocytes exhibit parthenogenic activation

cellular
abnormal female meiosis ( J:360869 )
• most oocytes have either one or several chromosomes separated from the main group of chromosomes
• oocytes remain alive in the ovaries and progress further in meiosis through germinal vesicle to the second metaphase (MII) stage, however approximately 25% of MII oocytes exhibit chromosomal segregation and chromatin organization abnormalities, with meiotic spindle disruption, scattered chromosomes, parthenogenic activation, and large, seemingly empty or fluid-filled follicles within the cytosol
parthenogenesis ( J:360869 )
• some MII oocytes exhibit parthenogenic activation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory