Phenotypes associated with this allele

• Allele Symbol: Rnf145^em1Pton
• Allele Name: endonuclease-mediated mutation 1, Peter Tontonoz
• Allele ID: MGI:8162185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf145^em1Pton/Rnf145^em1Pton	Not Specified	MGI:8321902

Genotype
MGI:8321902

hm1

• Allelic Composition: Rnf145^em1Pton/Rnf145^em1Pton
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:249975 )

• 4-week-old mice are overtly normal except for a slight but statistically significant reduction in body weight relative to wild-type littermates

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:249975 )

N • 4-week-old mice exhibit no significant differences in liver triglyceride levels or fasting blood glucose levels relative to wild-type littermates

abnormal cholesterol homeostasis ( J:249975 )

• following a 6 h fast, 4-week-old mice show a significant increase in the hepatic expression of several SREBP-2 target genes involved in the sterol synthesis pathway; gene ontology and pathway analysis indicates that the cholesterol biosynthetic pathway is coordinately upregulated in liver tissue

• however, liver cholesterol levels are not significantly altered relative to wild-type littermates

increased circulating cholesterol level ( J:249975 )

• 4-week-old mice exhibit a significant increase in serum cholesterol levels in both the LDL and HDL fractions relative to wild-type littermates

increased circulating HDL cholesterol level ( J:249975 )

increased circulating LDL cholesterol level ( J:249975 )