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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plaat3em1Ueda
endonuclease-mediated mutation 1, Natsuo Ueda
MGI:7868154
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plaat3em1Ueda/Plaat3em1Ueda C57BL/6NCrSlc-Plaat3em1Ueda MGI:8192609


Genotype
MGI:8192609
hm1
Allelic
Composition
Plaat3em1Ueda/Plaat3em1Ueda
Genetic
Background
C57BL/6NCrSlc-Plaat3em1Ueda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plaat3em1Ueda mutation (0 available); any Plaat3 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• when 8-week-old male mice are fed a high-fat diet (HFD) for 12 weeks, their weekly body weight gain is significantly lower than that of HFD-fed wild-type controls starting at week 1 after HFD feeding
• however, no differences in daily food intake, caloric intake, or water consumption are observed under standard chow (SD) or HFD feeding relative to diet-matched wild-type controls
• HFD-fed males appear grossly thinner than HFD-fed wild-type controls
• HFD-fed males exhibit enlarged livers
• males show a significant increase in actual and relative liver weight under both standard chow (SD) and HFD feeding conditions; increase in liver weight is significantly greater after 12 weeks on the HFD than on the SD

homeostasis/metabolism
• when 8-week-old male mice are fed a high-fat diet (HFD) for 12 weeks, their weekly body weight gain is significantly lower than that of HFD-fed wild-type controls starting at week 1 after HFD feeding
• however, no differences in daily food intake, caloric intake, or water consumption are observed under standard chow (SD) or HFD feeding relative to diet-matched wild-type controls
• after a 5-h fast, plasma insulin levels are significantly higher than those in wild-type controls
• in an intraperitoneal insulin tolerance test (ITT), plasma glucose levels are hardly reduced at 90 min after insulin injection; AUC value is significantly higher than that in wild-type controls, indicating insulin resistance
• after a 5-h fast, plasma adiponectin levels are significantly lower than those in wild-type controls
• males show a marked reduction of phospholipase A1/A2 (PLA1/A2) activity in white adipose tissue (WAT) relative to wild-type controls
• however, N-acyltransferase activity is negligible in WAT and comparable to that in wild-type controls

liver/biliary system
• HFD-fed males exhibit enlarged livers
• males show a significant increase in actual and relative liver weight under both standard chow (SD) and HFD feeding conditions; increase in liver weight is significantly greater after 12 weeks on the HFD than on the SD
• HFD-fed males exhibit significantly more hepatic lipid accumulation than HFD-fed wild-type controls, as indicated by oil red O and H&E staining
• HFD-fed males exhibit whitish livers

adipose tissue
• HFD-fed males show decreased white adipocyte size upon H&E staining; the frequency of medium (400-799 um2) and large (800-3000 um2) adipocytes is significantly lower than that in HFD-fed wild-type controls
• males show a significant decrease in total and relative WAT weight under both SD and HFD feeding conditions
• HFD-fed males show substantial infiltration of F4/80+ macrophages and significantly higher mRNA expression of Adgre1 (encoding F4/80) in WAT than HFD-fed wild-type controls, suggesting that inflammation is exacerbated by macrophages

immune system
• HFD-fed males show substantial infiltration of F4/80+ macrophages and significantly higher mRNA expression of Adgre1 (encoding F4/80) in WAT than HFD-fed wild-type controls, suggesting that inflammation is exacerbated by macrophages

muscle
• males show a significant decrease in gastrocnemius weight under both SD and HFD feeding conditions; reduction in gastrocnemius weight is significantly smaller on the HFD than on the SD
• HFD-fed males show a significant decrease in the total weight of quadriceps, tibialis anterior, gastrocnemius and soleus muscles relative to HFD-fed wild-type controls
• however, total skeletal muscle weight is not significantly altered on the SD and femur weight is normal under both SD and HFD feeding

limbs/digits/tail
• males show a significant decrease in gastrocnemius weight under both SD and HFD feeding conditions; reduction in gastrocnemius weight is significantly smaller on the HFD than on the SD





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory