Phenotypes associated with this allele

• Allele Symbol: Sh2b3^em3Cgv
• Allele Name: endonuclease-mediated mutation 3, Carola Vinuesa
• Allele ID: MGI:7863634
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2b3^em3Cgv/Sh2b3^em3Cgv	C57BL/6NCrl-Sh2b3^em3Cgv	MGI:8277031
ht2	Sh2b3^em3Cgv/Sh2b3^+	C57BL/6NCrl-Sh2b3^em3Cgv	MGI:8277032

Genotype
MGI:8277031

hm1

• Allelic Composition: Sh2b3^em3Cgv/Sh2b3^em3Cgv
• Genetic Background: C57BL/6NCrl-Sh2b3^em3Cgv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:358257 )

• mild splenomegaly

spleen hyperplasia ( J:358257 )

• increase in spleen cellularity

increased leukocyte cell number ( J:358257 )

• large increase in peripheral blood leukocyte count

increased lymphocyte cell number ( J:358257 )

• large increase in peripheral blood lymphocyte count

increased B cell number ( J:358257 )

• total number of B cells is increased

• however, frequency of splenic B cells is unchanged

increased transitional stage B cell number ( J:358257 )

• increase in frequency of splenic transitional B cells, primarily within the transitional 1 (T1) B cell compartment, with a milder increase in transitional 2 (T2) and 3 (T3) B cells

increased T cell number ( J:358257 )

• total number of T cells is increased

• however, frequency of splenic T cells is unchanged

abnormal spleen marginal zone morphology ( J:358257 )

• decrease in marginal zone (MZ) B cells, however, this change is not due to a reduction of MZ B cell numbers but an increase in the other mature B cell subsets in the marginal zone

hematopoietic system

enlarged spleen ( J:358257 )

• mild splenomegaly

spleen hyperplasia ( J:358257 )

• increase in spleen cellularity

increased leukocyte cell number ( J:358257 )

• large increase in peripheral blood leukocyte count

increased lymphocyte cell number ( J:358257 )

• large increase in peripheral blood lymphocyte count

increased B cell number ( J:358257 )

• total number of B cells is increased

• however, frequency of splenic B cells is unchanged

increased transitional stage B cell number ( J:358257 )

• increase in frequency of splenic transitional B cells, primarily within the transitional 1 (T1) B cell compartment, with a milder increase in transitional 2 (T2) and 3 (T3) B cells

increased T cell number ( J:358257 )

• total number of T cells is increased

• however, frequency of splenic T cells is unchanged

abnormal spleen marginal zone morphology ( J:358257 )

• decrease in marginal zone (MZ) B cells, however, this change is not due to a reduction of MZ B cell numbers but an increase in the other mature B cell subsets in the marginal zone

growth/size/body

enlarged spleen ( J:358257 )

• mild splenomegaly

spleen hyperplasia ( J:358257 )

• increase in spleen cellularity

Genotype
MGI:8277032

ht2

• Allelic Composition: Sh2b3^em3Cgv/Sh2b3⁺
• Genetic Background: C57BL/6NCrl-Sh2b3^em3Cgv

hematopoietic system

increased transitional stage B cell number ( J:358257 )

• increase in frequency of splenic transitional B cells

immune system

increased transitional stage B cell number ( J:358257 )

• increase in frequency of splenic transitional B cells