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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pqbp1em1Jhhan
endonuclease-mediated mutation 1, Junhai Han
MGI:7797303
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pqbp1em1Jhhan/Pqbp1em1Jhhan C57BL/6J-Pqbp1em1Jhhan MGI:7797375
ot2
 		Pqbp1em1Jhhan/Y C57BL/6J-Pqbp1em1Jhhan MGI:7797376


Genotype
MGI:7797375
hm1
Allelic
Composition		 Pqbp1em1Jhhan/Pqbp1em1Jhhan
Genetic
Background		 C57BL/6J-Pqbp1em1Jhhan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pqbp1em1Jhhan mutation (0 available); any Pqbp1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:353600 )
• significantly reduced body weight at age P60
microcephaly ( J:353600 )
• at age P60

nervous system
nervous system phenotype ( J:353600 )
N
• normal cerebral cortex stratification
decreased brain weight ( J:353600 )
• significantly reduced brain weight at age P60
thin cerebral cortex ( J:353600 )
• at age P60
abnormal neuronal precursor cell number ( J:353600 )
• increased number of differentiated and non-proliferating NSPCs in E14.5 embryos
decreased neuronal precursor cell number ( J:353600 )
• reduction in intermediate precursors in E14.5 embryos




Genotype
MGI:7797376
ot2
Allelic
Composition		 Pqbp1em1Jhhan/Y
Genetic
Background		 C57BL/6J-Pqbp1em1Jhhan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pqbp1em1Jhhan mutation (0 available); any Pqbp1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:353600 )
• significantly reduced body weight at age P60
microcephaly ( J:353600 )
• at age P60

nervous system
nervous system phenotype ( J:353600 )
• normal cerebral cortex stratification
decreased brain weight ( J:353600 )
• significantly reduced brain weight at age P60
thin cerebral cortex ( J:353600 )
• at age P60
abnormal neuronal precursor cell number ( J:353600 )
• increased number of differentiated and non-proliferating NSPCs in E14.5 embryos
decreased neuronal precursor cell number ( J:353600 )
• reduction in intermediate precursors in E14.5 embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory