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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snip1em1Yiji
endonuclease-mediated mutation 1, Yichang Jia
MGI:7738204
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Snip1em1Yiji/Snip1em1Yiji C57BL/6J-Snip1em1Yiji MGI:7738301
ht2
 		Snip1em1Yiji/Snip1+ C57BL/6J-Snip1em1Yiji MGI:7738300
cx3
 		Rnu2-8nmf291/Rnu2-8nmf291
Snip1em1Yiji/Snip1+ 		involves: 129S4/SvJae * C57BL/6J MGI:7738298


Genotype
MGI:7738301
hm1
Allelic
Composition		 Snip1em1Yiji/Snip1em1Yiji
Genetic
Background		 C57BL/6J-Snip1em1Yiji
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snip1em1Yiji mutation (0 available); any Snip1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:354967 )
• no homozygotes are obtained




Genotype
MGI:7738300
ht2
Allelic
Composition		 Snip1em1Yiji/Snip1+
Genetic
Background		 C57BL/6J-Snip1em1Yiji
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snip1em1Yiji mutation (0 available); any Snip1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:354967 )
N
• mice do not exhibit neuron loss in the cerebellum




Genotype
MGI:7738298
cx3
Allelic
Composition		 Rnu2-8nmf291/Rnu2-8nmf291
Snip1em1Yiji/Snip1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnu2-8nmf291 mutation (1 available); any Rnu2-8 mutation (1 available)
Snip1em1Yiji mutation (0 available); any Snip1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:354967 )
N
• mice exhibit rescue of the ataxia seen in Rnu2-8nmf291/nmf291 homozygotes

mortality/aging
extended life span ( J:354967 )
• mice exhibit extended life span compared to Rnu2-8nmf291/nmf291 homozygotes

nervous system
neuron degeneration ( J:354967 )
• mice exhibit partial rescue of the neuron loss seen in Rnu2-8nmf291/nmf291 homozygous cerebellum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory