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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rps27em1Mbar
endonuclease-mediated mutation 1, Maria Barna
MGI:7703428
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rps27em1Mbar/Rps27em1Mbar C57BL/6J-Rps27em1Mbar MGI:7703449
cx2
 		Rps27em1Mbar/Rps27em1Mbar
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * C57BL/6J MGI:7703462
cx3
 		Rps27em1Mbar/Rps27em1Mbar
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6J MGI:7703467


Genotype
MGI:7703449
hm1
Allelic
Composition		 Rps27em1Mbar/Rps27em1Mbar
Genetic
Background		 C57BL/6J-Rps27em1Mbar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27em1Mbar mutation (0 available); any Rps27 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:351545 )
• only a single embryo is found at E8.5 and that was severely delayed




Genotype
MGI:7703462
cx2
Allelic
Composition		 Rps27em1Mbar/Rps27em1Mbar
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27em1Mbar mutation (0 available); any Rps27 mutation (6 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7703467
cx3
Allelic
Composition		 Rps27em1Mbar/Rps27em1Mbar
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27em1Mbar mutation (0 available); any Rps27 mutation (6 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory