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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc22a18tm1Tgot
targeted mutation 1, Takanari Gotoda
MGI:7657433
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc22a18tm1Tgot/Slc22a18tm1Tgot B6.Cg-Slc22a18tm1Tgot MGI:7657454
cx2
 		Lepob/Lepob
Slc22a18tm1Tgot/Slc22a18tm1Tgot 		involves: C57BL/6 MGI:7657458


Genotype
MGI:7657454
hm1
Allelic
Composition		 Slc22a18tm1Tgot/Slc22a18tm1Tgot
Genetic
Background		 B6.Cg-Slc22a18tm1Tgot
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc22a18tm1Tgot mutation (0 available); any Slc22a18 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver triglyceride level ( J:349247 )
• under refeeding conditions after fasting, hepatic triglyceride content is reduced

homeostasis/metabolism
decreased liver triglyceride level ( J:349247 )
• under refeeding conditions after fasting, hepatic triglyceride content is reduced

growth/size/body
growth/size/body region phenotype ( J:349247 )
N
• mice show normal growth, food intake, and organ weight




Genotype
MGI:7657458
cx2
Allelic
Composition		 Lepob/Lepob
Slc22a18tm1Tgot/Slc22a18tm1Tgot
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (20 available)
Slc22a18tm1Tgot mutation (0 available); any Slc22a18 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
abnormal epididymal fat pad morphology ( J:349247 )
• mice show reduced epididymal fat mass compared to single Leprob homozygotes

liver/biliary system
decreased liver weight ( J:349247 )
• mice tend to show lower liver weight than single Leprob homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory