About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnt1em1Lekk
endonuclease-mediated mutation 1, Leonard K Kaczmarek
MGI:7624374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnt1em1Lekk/Kcnt1em1Lekk C57BL/6J-Kcnt1em1Lekk MGI:7624382
ht2
 		Kcnt1em1Lekk/Kcnt1+ C57BL/6J-Kcnt1em1Lekk MGI:7624379


Genotype
MGI:7624382
hm1
Allelic
Composition		 Kcnt1em1Lekk/Kcnt1em1Lekk
Genetic
Background		 C57BL/6J-Kcnt1em1Lekk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1em1Lekk mutation (0 available); any Kcnt1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7624379
ht2
Allelic
Composition		 Kcnt1em1Lekk/Kcnt1+
Genetic
Background		 C57BL/6J-Kcnt1em1Lekk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1em1Lekk mutation (0 available); any Kcnt1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:287751 )
N
• normal behavior in open field test
seizures ( J:287751 )
• spontaneous electrographic seizures and persistent interictal spikes
increased susceptibility to pharmacologically induced seizures ( J:287751 )
• convulsive (phase 3) seizures after PTZ administration

nervous system
seizures ( J:287751 )
• spontaneous electrographic seizures and persistent interictal spikes
increased susceptibility to pharmacologically induced seizures ( J:287751 )
• convulsive (phase 3) seizures after PTZ administration

mortality/aging
mortality/aging ( J:287751 )
N
• normal survival

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 14 DOID:0080439 OMIM:614959
 J:287751




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory