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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Xrn1em1Tya
endonuclease-mediated mutation 1, Tadashi Yamamoto
MGI:7621399
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Xrn1em1Tya/Xrn1em1Tya
Tg(Camk2a-cre)2Gsc/0
involves: C57BL/6N * FVB/N MGI:7621403


Genotype
MGI:7621403
cn1
Allelic
Composition
Xrn1em1Tya/Xrn1em1Tya
Tg(Camk2a-cre)2Gsc/0
Genetic
Background
involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-cre)2Gsc mutation (2 available)
Xrn1em1Tya mutation (0 available); any Xrn1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in males, but not females, at 3-4 weeks of age
• rapidly gain weight after 5 weeks of age, with both males and females showing increased body weight by 6 weeks of age
• leptin treatment fails to decrease body weight
• at 12 weeks of age

adipose tissue
• increase in inguinal and epididymal white adipose tissue weight
• drastically enlarged in inguinal and epididymal white adipose tissue
• reduced expression of Ucp1 indicates impaired lipid metabolism

homeostasis/metabolism
• at 13 weeks of age but not at 5 or 6 weeks of age in males
• fed and fasting glucose levels are increased in mice at 9 weeks of age
• at 5 weeks of age before the onset of obesity
• also increased at 15 weeks of age
• at 6 weeks of age an increase in the respiratory exchange ratio but little change in overall energy expenditure
• at 5 weeks of age
• at 5 weeks of age
• the respiratory exchange ratio remains constant around 1.0 indicating that only carbohydrates are used as an energy source

behavior/neurological
• in males and females over 6 weeks of age
• leptin treatment fails to decrease food intake
• no difference in home cage activity at 12 weeks of age

nervous system
• upregulation of appetite and energy-homeostasis related genes at 14 weeks of age

liver/biliary system
• lipid accumulation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory