Phenotypes associated with this allele

• Allele Symbol: Ube2s^tm1.1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:7621220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2s^tm1.1Smoc/Ube2s^tm1.1Smoc	involves: C57BL/6	MGI:7621230
hm2	Ube2s^tm1.1Smoc/Ube2s^tm1.1Smoc	Not Specified	MGI:7621248

Genotype
MGI:7621230

hm1

• Allelic Composition: Ube2s^tm1.1Smoc/Ube2s^tm1.1Smoc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:306461 )

• reduced mortality following EMCV infection

immune system

abnormal macrophage physiology ( J:306461 )

• elevated Ifnb1 expression in cultured macrophages in response to viral infection

increased circulating interleukin-6 level ( J:306461 )

• following EMCV, HSV-1, or VSV infection

increased circulating tumor necrosis factor level ( J:306461 )

• elevated after VSV or HSV-1 infection

increased interferon level ( J:306461 )

• elevated levels of Ifnb1 in the heart and brain 48 and 72 hours following EMCV injection

• elevation is also seen after infection with VSV

increased circulating interferon-alpha level ( J:306461 )

• elevated Ifna4 levels following VSV or HSV-1 infection

increased circulating interferon-beta level ( J:306461 )

• following EMCV, HSV-1, or VSV infection

increased interferon-beta secretion ( J:306461 )

• in macrophages following viral infection

decreased susceptibility to Herpesvirales infection ( J:306461 )

• lower titers of herpes simplex virus 1 (HSV-1) in the brain

decreased susceptibility to Riboviria infection ( J:306461 )

• following infection with vesicular stomatitis virus (VSV) viral titers are lower in liver spleen and lung

decreased susceptibility to Picornaviridae infection ( J:306461 )

• following infection with encephalomyocarditis virus (EMCV) viral titers in heart and brain are lower, fewer signs of severe inflammation are seen in the heart and brain, and few signs of nerve cell degeneration and inflammatory cell infiltration in the brain

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:306461 )

• reduced mortality following EMCV infection

homeostasis/metabolism

increased circulating interleukin-6 level ( J:306461 )

• following EMCV, HSV-1, or VSV infection

increased circulating tumor necrosis factor level ( J:306461 )

• elevated after VSV or HSV-1 infection

increased interferon level ( J:306461 )

• elevated levels of Ifnb1 in the heart and brain 48 and 72 hours following EMCV injection

• elevation is also seen after infection with VSV

increased circulating interferon-alpha level ( J:306461 )

• elevated Ifna4 levels following VSV or HSV-1 infection

increased circulating interferon-beta level ( J:306461 )

• following EMCV, HSV-1, or VSV infection

hematopoietic system

abnormal macrophage physiology ( J:306461 )

• elevated Ifnb1 expression in cultured macrophages in response to viral infection

Genotype
MGI:7621248

hm2

• Allelic Composition: Ube2s^tm1.1Smoc/Ube2s^tm1.1Smoc
• Genetic Background: Not Specified

reproductive system

reproductive system phenotype ( J:346998 )

♀N • no abnormalities in ovaries, uterus, or numbers of normal or superovulated oocytes

abnormal female meiosis ( J:346998 )

♀ • failure of homologous chromosome separation

♀ • however, spindles are well organized at 4 and 6 h after germinal vesicle breakdown

♀ • impaired degradation of anaphase promoting complex/cyclosome substrates during metaphase I to anaphase I transition

abnormal female meiosis I arrest ( J:346998 )

♀ • rarely show first polar body extrusion at 12 h after human chorionic gonadotropin injection suggesting an arrest at meiosis I

♀ • arrest at metaphase I

♀ • activation with strontium (a parthenogenetic agent) can induce a polar body extrusion

female infertility ( J:346998 )

♀ • following matings with wild-type males pregnancies are observed but no pups are born

♀ • embryos degenerate between E9.5 and E10.5

♀ • most zygotes are triploid

cellular

abnormal female meiosis ( J:346998 )

♀ • failure of homologous chromosome separation

♀ • however, spindles are well organized at 4 and 6 h after germinal vesicle breakdown

♀ • impaired degradation of anaphase promoting complex/cyclosome substrates during metaphase I to anaphase I transition

abnormal female meiosis I arrest ( J:346998 )

♀ • rarely show first polar body extrusion at 12 h after human chorionic gonadotropin injection suggesting an arrest at meiosis I

♀ • arrest at metaphase I

♀ • activation with strontium (a parthenogenetic agent) can induce a polar body extrusion