Ube2s^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Ube2s^tm1.1Smoc
• Name: ubiquitin-conjugating enzyme E2S; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7621220
• Gene: Ube2s Location: Chr7:4811013-4815339 bp, - strand Genetic Position: Chr7, 2.78 cM
• Alliance: Ube2s^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3. Cre mediated recombination removed exons 2 and 3 and the neo cassette. (J:306461)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2s Mutation: 14 strains or lines available

References

• Original: J:306461 Huang L, et al., Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Rep. 2020 Aug 18;32(7):108044
• All: 2 reference(s)