Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pogzem1Tnkw mutation
(0 available);
any
Pogz mutation
(52 available)
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cardiovascular system
mortality/aging
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• embryos succumb to VSD (ventricular septal defect)
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Allelic Composition |
Pogzem1Tnkw/Pogz+
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Genetic Background |
involves: C57BL/6NJcl |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pogzem1Tnkw mutation
(0 available);
any
Pogz mutation
(52 available)
|
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behavior/neurological
N |
• normal behavior in elevated Y maze test and light/dark transition tests
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• less time spent interacting (allogrooming, chasing, playing, sniffing) with other mice in juveniles
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• increased light phase home cage activity to total home cage activity ratio
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• lower % freezing time in contextual fear conditioning test
• normal auditory cued fear conditioning behavior
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• more time spent in central area in open field test
• normal total locomotor activity
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• less time spent with novel object
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• less time spent with novel mice
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• increased time spent self-grooming
• less time spent allogrooming in juveniles
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• altered isolation-induced ultrasonic vocalization (USV) call patterns emitted by mouse pups separated from their mothers
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nervous system
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• decreased upper layer and increased lower layer SATB2+ excitatory neuron density in cortical layer II/III of E18.5 embryos
• decreased upper layer and increased lower layer CUX1+ excitatory neuron density in cortical layer II/III at age 10 weeks
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• in anterior cingulate cortex (ACC) layer II/II pyramidal neurons at age 10 weeks
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• miniature excitatory postsynaptic current (mEPSC) frequency in anterior cingulate cortex (ACC) layer II/II pyramidal neurons at age 10 weeks
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embryo
N |
• mice born at expected Mendelian ratios
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growth/size/body
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• at all ages up to 12 weeks
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hearing/vestibular/ear
N |
• normal cochlea morphology
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muscle
N |
• no diaphragmatic hernia
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respiratory system
N |
• normal trachea morphology
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skeleton
N |
• normal skull morphology
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vision/eye
digestive/alimentary system
N |
• normal stomach, duodenum, ileum, cecum and colon morphology
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