About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Alpk1em1Dlka
endonuclease-mediated mutation 1, Daniel L Kastner
MGI:7614851
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Alpk1em1Dlka/Alpk1+
Crb1rd8/Crb1+ 		involves: C57BL/6J * C57BL/6N MGI:7614876
cx2
 		Alpk1em1Dlka/Alpk1em1Dlka
Crb1rd8/Crb1rd8 		involves: C57BL/6N MGI:7614873


Genotype
MGI:7614876
cx1
Allelic
Composition		 Alpk1em1Dlka/Alpk1+
Crb1rd8/Crb1+
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpk1em1Dlka mutation (0 available); any Alpk1 mutation (78 available)
Crb1rd8 mutation (18 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:344848 )
N
• normal fundus morphology and ERG amplitudes at age 9 and 12 months




Genotype
MGI:7614873
cx2
Allelic
Composition		 Alpk1em1Dlka/Alpk1em1Dlka
Crb1rd8/Crb1rd8
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpk1em1Dlka mutation (0 available); any Alpk1 mutation (78 available)
Crb1rd8 mutation (18 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:344848 )
N
• normal body and spleen weight at age 6, 12 and 16 weeks

homeostasis/metabolism
abnormal circulating chemokine level ( J:344848 )
• increased serum CXCL1 and CCL2 levels at age 2 and 3 months
increased circulating CXCL10 level ( J:344848 )
• increased serum CXCL10 levels at age 2 and 3 months

immune system
immune system phenotype ( J:344848 )
N
• normal spleen weight at age 6, 12 and 16 weeks
abnormal circulating chemokine level ( J:344848 )
• increased serum CXCL1 and CCL2 levels at age 2 and 3 months
increased circulating CXCL10 level ( J:344848 )
• increased serum CXCL10 levels at age 2 and 3 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory