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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cib3em1Xuzg
endonuclease-mediated mutation 2, Zhigang Xu
MGI:7612574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cib3em1Xuzg/Cib3em1Xuzg C57BL/6N-Cib3em1Xuzg MGI:7612577
cx2
 		Cib2em1Xuzg/Cib2em1Xuzg
Cib3em1Xuzg/Cib3em1Xuzg 		involves: C57BL/6 * C57BL/6N MGI:7612578


Genotype
MGI:7612577
hm1
Allelic
Composition		 Cib3em1Xuzg/Cib3em1Xuzg
Genetic
Background		 C57BL/6N-Cib3em1Xuzg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cib3em1Xuzg mutation (0 available); any Cib3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased vestibular hair cell stereocilia number ( J:345936 )
• at 90 days of age but not at 30 days of age in the utricle and the extrstriolar region of the saccule
• severity is increased at P180

behavior/neurological
impaired balance ( J:345936 )
• detected in a swimming test at 3 months of age and becomes more severe with age

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:345936 )
N
• no defects in hearing threshold at up to 11 months of age
decreased vestibular hair cell stereocilia number ( J:345936 )
• at 90 days of age but not at 30 days of age in the utricle and the extrstriolar region of the saccule
• severity is increased at P180




Genotype
MGI:7612578
cx2
Allelic
Composition		 Cib2em1Xuzg/Cib2em1Xuzg
Cib3em1Xuzg/Cib3em1Xuzg
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cib2em1Xuzg mutation (0 available); any Cib2 mutation (15 available)
Cib3em1Xuzg mutation (0 available); any Cib3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
decreased vestibular hair cell stereocilia number ( J:345936 )
• starting at P15 in the striolar and extrastriolar regions of saccules and utricles and increasing in severity at P30 and P90
abnormal hair cell mechanoelectric transduction ( J:345936 )
• mechanoelectric transduction currents are completely abolished in both striolar and extrastriolar vestibular hair cells

behavior/neurological
impaired balance ( J:345936 )
• severe impairment at P30 in both the rotarod and swimming tests
circling ( J:345936 )
• at P30

nervous system
decreased vestibular hair cell stereocilia number ( J:345936 )
• starting at P15 in the striolar and extrastriolar regions of saccules and utricles and increasing in severity at P30 and P90
abnormal hair cell mechanoelectric transduction ( J:345936 )
• mechanoelectric transduction currents are completely abolished in both striolar and extrastriolar vestibular hair cells




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory