Cib2^em1Xuzg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cib2^em1Xuzg
• Name: calcium and integrin binding family member 2; endonuclease-mediated mutation 2, Zhigang Xu
• MGI ID: MGI:7612327
• Gene: Cib2 Location: Chr9:54452078-54467502 bp, - strand Genetic Position: Chr9, 29.7 cM
• Alliance: Cib2^em1Xuzg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs created two deletions of 9 bp and 8 bp in exon 4 resulting in a premature stop codon. RT-PCR confirmed the absence of full length transcript and very low levels of a truncated transcript. (J:280151)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cib2 Mutation: 15 strains or lines available

References

• Original: J:280151 Wang Y, et al., Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Front Mol Neurosci. 2017;10:401
• All: 2 reference(s)