Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Phf5atm1.1Oux mutation
(0 available);
any
Phf5a mutation
(18 available)
Tg(IghelMD4)4Ccg mutation
(3 available)
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hematopoietic system
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• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells
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immune system
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• addition of a pre-rearranged IgH transgene partially but significantly increases the number of CD19+ B cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Phf5atm1.1Oux mutation
(0 available);
any
Phf5a mutation
(18 available)
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hematopoietic system
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• defect in RAG-mediated recombination
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• significant reduction in the diversity of IgH chain repetoires
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• decreased absolute numbers of BP1- CD24+ early pro-B cells
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• decreased absolute numbers of BP1+ CD24high late pro-B cells
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• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
• no increase in proliferation of pre-pro-B cells
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• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
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• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
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• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
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• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
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• defect in IgH chain gene expression in pre-pro-B cells
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immune system
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• defect in RAG-mediated recombination
|
|
• significant reduction in the diversity of IgH chain repetoires
|
|
• decreased absolute numbers of BP1- CD24+ early pro-B cells
|
|
• decreased absolute numbers of BP1+ CD24high late pro-B cells
|
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• increase in frequency and absolute number of BP1- CD24- pre-pro-B cells
• no increase in proliferation of pre-pro-B cells
|
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• approximately sixfold decrease in both percentage and total number of B220+ B cells in the bone marrow
• percentages and absolute numbers of B220+ CD43- late-stage B cells and B220high CD43- recirculating B cells are decreased
• severe B lymphopenia in the periphery
|
|
• drastically reduced B220+ CD43+ IgM+ IgD- immature B cell numbers
|
|
• dramatic reduction in the number of B220+ splenic B cells
• IgD+ mature B cells are virtually absent in the spleen
|
|
• drastically reduced B220+ CD43- IgM- IgD- small pre-B cell numbers
|
|
• defect in IgH chain gene expression in pre-pro-B cells
|