Phenotypes associated with this allele

• Allele Symbol: Ing5^tm1.1Avo
• Allele Name: targeted mutation 1.1, Anne K Voss
• Allele ID: MGI:7596133
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ing5^tm1.1Avo/Ing5^tm1.1Avo	B6.Cg-Ing5^tm1.1Avo	MGI:7596135
ht2	Ing5^tm1.1Avo/Ing5^+	B6.Cg-Ing5^tm1.1Avo	MGI:7596139

Genotype
MGI:7596135

hm1

• Allelic Composition: Ing5^tm1.1Avo/Ing5^tm1.1Avo
• Genetic Background: B6.Cg-Ing5^tm1.1Avo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:345308 )

• only 1/3 of the expected number found at weaning

growth/size/body

decreased fetal size ( J:345308 )

• smaller at E18.5

• moderate reduction in size at E14.5

liver/biliary system

liver hypoplasia ( J:345308 )

• at E14.5 even when reduction in body size is taken into account

hematopoietic system

abnormal proerythroblast morphology ( J:345308 )

• accumulation of proerythroblasts at E14.5

decreased fetal derived definitive erythrocyte cell number ( J:345308 )

abnormal fetal liver hematopoietic progenitor cell morphology ( J:345308 )

• decrease in the number of lineage negative c-Kit positive progenitor cells in the fetal liver at E14.5

• decrease in the hematopoietic progenitor cell 2 and hematopoietic stem cell populations at E14.5

• transplantation of fetal liver cells indicates the defects are not cell intrinsic

spleen hypoplasia ( J:345308 )

• at E18.5

immune system

spleen hypoplasia ( J:345308 )

• at E18.5

Genotype
MGI:7596139

ht2

• Allelic Composition: Ing5^tm1.1Avo/Ing5⁺
• Genetic Background: B6.Cg-Ing5^tm1.1Avo

hematopoietic system

abnormal proerythroblast morphology ( J:345308 )

• accumulation of proerythroblasts at E14.5