Ing5^tm1.1Ttho
Targeted Allele Detail

Summary

• Symbol: Ing5^tm1.1Ttho
• Name: inhibitor of growth family, member 5; targeted mutation 1.1, Tim Thomas
• MGI ID: MGI:7596133
• Gene: Ing5 Location: Chr1:93731687-93749823 bp, + strand Genetic Position: Chr1, 47.34 cM, cytoband D
• Alliance: Ing5^tm1.1Ttho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345308
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3 - 5. Quantitative RT-PCR confirmed the absence of RNA in homozygous embryos. (J:345308)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ing5 Mutation: 24 strains or lines available

References

• Original: J:345308 Mah SYY, et al., The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver. Front Immunol. 2023;14:1119750
• All: 1 reference(s)