Phenotypes associated with this allele

• Allele Symbol: Dtx3l^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7583470
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dtx3l^em1Cya/Dtx3l^em1Cya	C57BL/6JCya-Dtx3l^em1Cya/Cya	MGI:8473916

Genotype
MGI:8473916

hm1

• Allelic Composition: Dtx3l^em1Cya/Dtx3l^em1Cya
• Genetic Background: C57BL/6JCya-Dtx3l^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to viral infection induced morbidity/mortality ( J:369823 )

• in VSV-infected mice

immune system

increased circulating interferon-beta level ( J:369823 )

• in VSV-infected mice

increased circulating interleukin-6 level ( J:369823 )

• in VSV-infected mice

increased circulating tumor necrosis factor level ( J:369823 )

• in VSV-infected mice

increased susceptibility to viral infection ( J:369823 )

• VSV-infected mice exhibit elevated IFNbeta, TNFA, and IL6 serum levels compared with wild-type mice

• VSV-infected mice exhibit decreased viral load, reduced immune cell infiltration, and increased lethality compared with wild-type mice

increased susceptibility to viral infection induced morbidity/mortality ( J:369823 )

• in VSV-infected mice

homeostasis/metabolism

increased circulating interferon-beta level ( J:369823 )

• in VSV-infected mice

increased circulating interleukin-6 level ( J:369823 )

• in VSV-infected mice

increased circulating tumor necrosis factor level ( J:369823 )

• in VSV-infected mice