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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lancl2tm2c(KOMP)Wtsi
targeted mutation 2c, Wellcome Trust Sanger Institute
MGI:7580959
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lancl2tm2c(KOMP)Wtsi/Lancl2tm2c(KOMP)Wtsi
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: C57BL/6N MGI:7580961


Genotype
MGI:7580961
cn1
Allelic
Composition		 Lancl2tm2c(KOMP)Wtsi/Lancl2tm2c(KOMP)Wtsi
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lancl2tm2c(KOMP)Wtsi mutation (0 available); any Lancl2 mutation (22 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased regulatory T cell number ( J:250673 )
• reduction in Tr1 (CD4+FOXP3-PD1hiIL10+) cells was observed at three weeks post H. pylori infection
decreased macrophage cell number ( J:250673 )
• significant reduction in CX3CR1+ IL10-producing macrophages at three weeks post H. pylori infection

immune system
decreased regulatory T cell number ( J:250673 )
• reduction in Tr1 (CD4+FOXP3-PD1hiIL10+) cells was observed at three weeks post H. pylori infection
decreased macrophage cell number ( J:250673 )
• significant reduction in CX3CR1+ IL10-producing macrophages at three weeks post H. pylori infection
decreased susceptibility to bacterial infection ( J:250673 )
• the gastric luminal burden of H. pylori was significantly decreased in a model of H. pylori infection




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory