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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elac2em1Afi
endonuclease-mediated mutation 1, Aleksandra Filipovska
MGI:7545038
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elac2em1Afi/Elac2em1Afi C57BL/6N-Elac2em1Afi MGI:7545183
cx2
 		Elac2em1Afi/Elac2em1Afi
Tg(TRAMP)8247Ng/0 		involves: C57BL/6 * C57BL/6N MGI:7545187


Genotype
MGI:7545183
hm1
Allelic
Composition		 Elac2em1Afi/Elac2em1Afi
Genetic
Background		 C57BL/6N-Elac2em1Afi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elac2em1Afi mutation (0 available); any Elac2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland anterior lobe morphology ( J:336403 )
• disarrayed nuclei at age 30 weeks
• branching into lumen at age 30 weeks
• grade 2 lesions at age 30 weeks
prostate gland anterior lobe hyperplasia ( J:336403 )
• at ages 10 and 30 weeks
abnormal prostate gland dorsolateral lobe morphology ( J:336403 )
• stromal thickening in dorsal lobe at age 10 weeks
• papillary structures protruding into lumen at age 30 weeks
• focal grade 2 lesions at age 30 weeks
• cell crowding at age 30 weeks
• normal lateral lobe morphology at ages 10 and 30 weeks
prostate gland dorsolateral lobe hyperplasia ( J:336403 )
• dorsal lobe at age 30 weeks
prostate gland hyperplasia ( J:336403 )
• hyperplasia of dorsal lobe at age 30 weeks and anterior lobes at ages 10 and 30 weeks
prostate gland inflammation ( J:336403 )
• at age 30 weeks

immune system
prostate gland inflammation ( J:336403 )
• at age 30 weeks

reproductive system
reproductive system phenotype ( J:336403 )
N
• normal ventral and lateral lobe morphology at ages 10 and 30 weeks
abnormal prostate gland anterior lobe morphology ( J:336403 )
• disarrayed nuclei at age 30 weeks
• branching into lumen at age 30 weeks
• grade 2 lesions at age 30 weeks
prostate gland anterior lobe hyperplasia ( J:336403 )
• at ages 10 and 30 weeks
abnormal prostate gland dorsolateral lobe morphology ( J:336403 )
• stromal thickening in dorsal lobe at age 10 weeks
• papillary structures protruding into lumen at age 30 weeks
• focal grade 2 lesions at age 30 weeks
• cell crowding at age 30 weeks
• normal lateral lobe morphology at ages 10 and 30 weeks
prostate gland dorsolateral lobe hyperplasia ( J:336403 )
• dorsal lobe at age 30 weeks
prostate gland hyperplasia ( J:336403 )
• hyperplasia of dorsal lobe at age 30 weeks and anterior lobes at ages 10 and 30 weeks
prostate gland inflammation ( J:336403 )
• at age 30 weeks

mortality/aging
mortality/aging ( J:336403 )
N
• normal lifespan




Genotype
MGI:7545187
cx2
Allelic
Composition		 Elac2em1Afi/Elac2em1Afi
Tg(TRAMP)8247Ng/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elac2em1Afi mutation (0 available); any Elac2 mutation (38 available)
Tg(TRAMP)8247Ng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
prostate gland hyperplasia ( J:336403 )
• at age 30 weeks
abnormal seminal vesicle epithelium morphology ( J:336403 )
• substantial tumor formation at age 30 weeks
dilated seminal vesicle ( J:336403 )
• engorged at age 30 weeks

mortality/aging
premature death ( J:336403 )
• fewer mice live past 30 weeks and increased number die after 30 weeks owing to tumor load

neoplasm

reproductive system
prostate gland hyperplasia ( J:336403 )
• at age 30 weeks
abnormal seminal vesicle epithelium morphology ( J:336403 )
• substantial tumor formation at age 30 weeks
dilated seminal vesicle ( J:336403 )
• engorged at age 30 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory