All Phenotypes Elmo2<tm2.1Jfco> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elmo2^tm2.1Jfco
targeted mutation 2.1, Jean-Francois Cote
MGI:7544997

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129 * C57BL/6	MGI:7545146
cx2	Dysf^prmd/Dysf^prmd Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129 * A/J * C57BL/6	MGI:7545148
cx3	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco	involves: 129P2/OlaHsd * C57BL/6	MGI:7545147

Allelic Composition	Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

increased skeletal muscle fiber size ( J:331473 )

• with increased nuclei per fiber

enhanced skeletal muscle regeneration ( J:331473 )

• following cardiotoxin (CTX)-induced injury

• however, fiber size and nuclei number per fiber is like wild-type 7 days after CTX-induced injury

Allelic Composition	Dysf^prmd/Dysf^prmd Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129 * A/J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysf^prmd mutation (6 available); any Dysf mutation (183 available)
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:331473 )

N	• mice exhibit restored muscle regeneration following cardiotoxin-induced injury compared with Dysf^prmd homozygotes

Allelic Composition	Elmo1^tm1.2Ravi/Elmo1^tm1.2Ravi Elmo2^tm2.1Jfco/Elmo2^tm2.1Jfco
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elmo1^tm1.2Ravi mutation (0 available); any Elmo1 mutation (58 available)
Elmo2^tm2.1Jfco mutation (0 available); any Elmo2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331473 )

• no mice are present after weaning

embryonic lethality, incomplete penetrance ( J:331473 )

• fewer than expected mice are present at E14.5

embryo

abnormal embryo development ( J:331473 )

• at E14.5 and E16.5

• however, muscle development is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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