Elmo2^tm2.1Jfco
Targeted Allele Detail

Summary

• Symbol: Elmo2^tm2.1Jfco
• Name: engulfment and cell motility 2; targeted mutation 2.1, Jean-Francois Cote
• MGI ID: MGI:7544997
• Synonyms: Elmo2^EID
• Gene: Elmo2 Location: Chr2:165129951-165168399 bp, - strand Genetic Position: Chr2, 85.53 cM
• Alliance: Elmo2^tm2.1Jfco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct replaced exon 7 with one containing the mutation responsible for the amino acid substitution of isoleucine to aspartic acid at position 196 (I196D). This mutation abolishes the function of the ELMO inhibitory domain. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:331473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elmo2 Mutation: 37 strains or lines available

References

• Original: J:331473 Tran V, et al., Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Nat Commun. 2022 Nov 18;13(1):7077
• All: 1 reference(s)