Phenotypes associated with this allele

• Allele Symbol: Ntrk1^em1Krvl
• Allele Name: endonuclease-mediated mutation 1, Rejji Kuruvilla
• Allele ID: MGI:7544953
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk1^em1Krvl/Ntrk1^em1Krvl	C57BL/6J-Ntrk1^em1Krvl	MGI:7545026

Genotype
MGI:7545026

hm1

• Allelic Composition: Ntrk1^em1Krvl/Ntrk1^em1Krvl
• Genetic Background: C57BL/6J-Ntrk1^em1Krvl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:338830 )

N • normal sympathetic neuron proliferation in newborn (P0) mice

increased neuron apoptosis ( J:338830 )

• sympathetic neuron apoptosis in newborn (P0) mice

abnormal axon extension ( J:338830 )

• decreased innervation of sympathetic ganglion neuron targets (salivary glands, olfactory epithelium, eyes, and others) in E16 embryos, exacerbated in P0 mice and exacerbating further until P30 after which no further changes

• reduced responsiveness to NGF

abnormal sympathetic ganglion morphology ( J:338830 )

• smaller with fewer neurons in newborn (P0) mice, exacerbating until P30 after which no further changes

• normal in E16 embryos

growth/size/body

growth/size/body region phenotype ( J:338830 )

N • normal birth and adult body weight

mortality/aging

mortality/aging ( J:338830 )

N • survive to adulthood

cellular

increased neuron apoptosis ( J:338830 )

• sympathetic neuron apoptosis in newborn (P0) mice

abnormal axon extension ( J:338830 )

• decreased innervation of sympathetic ganglion neuron targets (salivary glands, olfactory epithelium, eyes, and others) in E16 embryos, exacerbated in P0 mice and exacerbating further until P30 after which no further changes

• reduced responsiveness to NGF

reproductive system

reproductive system phenotype ( J:338830 )

N • fertile

vision/eye

small pupil ( J:338830 )

• at age 6-8 weeks

• normal pupil constriction

blepharoptosis ( J:338830 )

• at age 6-8 weeks