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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dvl2tm1.2Wds
targeted mutation 1.2, William D Snider
MGI:7531373
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dvl2tm1.2Wds/Dvl2tm1.2Wds involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7531376
cx2
 		Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7560660
cx3
 		Dvl2tm1.2Wds/Dvl2tm1.2Wds
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7560661
cx4
 		Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7560662


Genotype
MGI:7531376
hm1
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2tm1.2Wds
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart development ( J:293794 )
• whole hearts from E12.5 embryos show a 60% reduction in Shroom3 expression; a global decrease in Shroom3 expression is seen throughout the heart, beginning at E10.5 and persisting through OFT formation and ventricular maturation at E11.5 and E12.5




Genotype
MGI:7560660
cx2
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (204 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:293794 )
• at E14.5, one embryo shows planar cell polarity (PCP) associated cardiac defects, including DORV and membranous VSD
double outlet right ventricle ( J:293794 )
• at E14.5, one embryo shows DORV
perimembraneous ventricular septal defect ( J:293794 )
• at E14.5, one embryo shows a membranous VSD




Genotype
MGI:7560661
cx3
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2tm1.2Wds
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (204 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:293794 )
• when Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2+ are crossed to Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2tm1.2Wds, no double knockout male mice are recovered at E14.5 (zero versus expected 4.75), indicating a gender bias due to Dvl2 loss




Genotype
MGI:7560662
cx4
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (204 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:293794 )
• when Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2+ are crossed to Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2tm1.2Wds, no male Shroom3Gt(ROSA53)SorShroom3Gt(ROSA53)Sor;Dvl2tm1.2Wds/Dvl2+ mice are recovered at E14.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory