Phenotypes associated with this allele

• Allele Symbol: Pik3r2^em1Gldn
• Allele Name: endonuclease-mediated mutation 1, Jeffrey A Golden
• Allele ID: MGI:7529483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3r2^em1Gldn/Pik3r2^em1Gldn	C57BL/6-Pik3r2^em1Gldn	MGI:7529509

Genotype
MGI:7529509

hm1

• Allelic Composition: Pik3r2^em1Gldn/Pik3r2^em1Gldn
• Genetic Background: C57BL/6-Pik3r2^em1Gldn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:304006 )

N • normal cortical lamination

N • no cortical or white matter dysplasia

N • normal cerebral cortical progenitor cell proliferation in E14.5 and E16.5 embryos

N • normal cerebral cortical progenitor cell cell cycle in E14.5 and E16.5 embryos

N • normal astrocyte size and number in brain

N • norm interneuron migration to cerebral cortex

increased brain size ( J:304006 )

• increased forebrain width and height

• normal brain size in E15.5 and E17.5 embryos

increased brain weight ( J:304006 )

• increased brain weight and brain-to-body weight ratio

dilated brain ventricle ( J:304006 )

thickened cerebral cortex ( J:304006 )

neuron hypertrophy ( J:304006 )

• increased cortical neuron soma size

cellular

abnormal cell nucleus morphology ( J:304006 )

• increased cortical cell nuclear size

reproductive system

reproductive system phenotype ( J:304006 )

N • fertile