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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem161bem1Jgg
endonuclease-mediated mutation 1, Joseph G Gleeson
MGI:7519190
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem161bem1Jgg/Tmem161bem1Jgg C57BL/6-Tmem161bem1Jgg MGI:7520265
ht2
 		Tmem161bem1Jgg/Tmem161bem3Jgg C57BL/6-Tmem161bem1Jgg/Tmem161bem3Jgg MGI:7520282


Genotype
MGI:7520265
hm1
Allelic
Composition		 Tmem161bem1Jgg/Tmem161bem1Jgg
Genetic
Background		 C57BL/6-Tmem161bem1Jgg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem161bem1Jgg mutation (0 available); any Tmem161b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:338312 )
N
• normal gross brain morphology in E18.5 embryos
abnormal radial glial cell morphology ( J:338312 )
• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos
abnormal stratification in cerebral cortex ( J:338312 )
• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into progenitor layers

cellular
abnormal radial glial cell morphology ( J:338312 )
• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

growth/size/body
growth/size/body region phenotype ( J:338312 )
N
• normal head size in E18.5 embryos

skeleton
skeleton phenotype ( J:338312 )
N
• normal cranium, jaw and snout morphology in E18.5 embryos

vision/eye
vision/eye phenotype ( J:338312 )
N
• normal retina pigment epithelium morphology in E18.5 embryos




Genotype
MGI:7520282
ht2
Allelic
Composition		 Tmem161bem1Jgg/Tmem161bem3Jgg
Genetic
Background		 C57BL/6-Tmem161bem1Jgg/Tmem161bem3Jgg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem161bem1Jgg mutation (0 available); any Tmem161b mutation (52 available)
Tmem161bem3Jgg mutation (0 available); any Tmem161b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:338312 )
• normal gross brain morphology in E18.5 embryos
abnormal radial glial cell morphology ( J:338312 )
• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos
abnormal stratification in cerebral cortex ( J:338312 )
• in E18.5 embryos owing to mislocated SATB2+ upper layer neurons into progenitor layers

cellular
abnormal radial glial cell morphology ( J:338312 )
• discontinuous SATB2+ fibers spanning from apical surface to pia in E18.5 embryos

growth/size/body
growth/size/body region phenotype ( J:338312 )
• normal head size in E18.5 embryos

skeleton
skeleton phenotype ( J:338312 )
• normal cranium, jaw and snout morphology in E18.5 embryos

vision/eye
vision/eye phenotype ( J:338312 )
• normal retina pigment epithelium morphology in E18.5 embryos




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory