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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxo22em1Mkt
endonuclease-mediated mutation 1, Makoto Nakanishi
MGI:7518950
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxo22em1Mkt/Fbxo22em1Mkt involves: C57BL/6N MGI:7518960


Genotype
MGI:7518960
hm1
Allelic
Composition		 Fbxo22em1Mkt/Fbxo22em1Mkt
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo22em1Mkt mutation (0 available); any Fbxo22 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:236274 )
• some die within a couple days of birth

cellular
abnormal cell physiology ( J:236274 )
• marked accumulation of Trp53 and Mdm2 in MEFs and tissues
decreased fibroblast proliferation ( J:236274 )
• MEFs show a severe growth defect with an increase in the G1 population




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory