Fbxo22^em1Mkt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxo22^em1Mkt
• Name: F-box protein 22; endonuclease-mediated mutation 1, Makoto Nakanishi
• MGI ID: MGI:7518950
• Synonyms: Fbxo22^-
• Gene: Fbxo22 Location: Chr9:55116219-55131717 bp, + strand Genetic Position: Chr9, 29.86 cM, cytoband C
• Alliance: Fbxo22^em1Mkt page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination using an sgRNA targeting exon 1 created a 17 bp deletion and a 3 bp insertion (GAT) (NM_028049.2:c.64_80delCTGAGTAACCTTGCGGAinsGAT:p.Leu22Aspfs*48). (J:236274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo22 Mutation: 33 strains or lines available

References

• Original: J:236274 Johmura Y, et al., SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence. Nat Commun. 2016 Feb 12;7:10574
• All: 1 reference(s)