All Phenotypes Bicra<em3Hzhg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bicra^em3Hzhg
endonuclease-mediated mutation 3, Honghe Zhang
MGI:7488661

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bicra^em3Hzhg/Bicra^em3Hzhg Tg(Tnnt2-cre)5Blh/0	involves: C57BL/6 * DBA/2	MGI:7543773
cn2	Bicra^em3Hzhg/Bicra^em3Hzhg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6J * CBA/J	MGI:7543774
cn3	Bicra^em3Hzhg/Bicra^em3Hzhg Tg(Cdh5-cre)7Mlia/0	involves: FVB/N	MGI:7543772

Allelic Composition	Bicra^em3Hzhg/Bicra^em3Hzhg Tg(Tnnt2-cre)5Blh/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicra^em3Hzhg mutation (0 available); any Bicra mutation (55 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:335098 )

N	• mice exhibit normal embryonic survival

cardiovascular system

cardiovascular system phenotype ( J:335098 )

N	• mice exhibit normal cardiac phenotype

Allelic Composition	Bicra^em3Hzhg/Bicra^em3Hzhg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicra^em3Hzhg mutation (0 available); any Bicra mutation (55 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:335098 )

neonatal lethality, incomplete penetrance ( J:335098 )

cardiovascular system

abnormal heart morphology ( J:335098 )

• at P0

double outlet right ventricle ( J:335098 )

• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum

ventricular septal defect ( J:335098 )

• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum

decreased cardiac output ( J:335098 )

• lower right ventricular output

abnormal coronary circulation ( J:335098 )

• transventricular septal flow

decreased ventricle muscle contractility ( J:335098 )

• reduced right ventricular output stroke volume and ejection fraction

growth/size/body

decreased body size ( J:335098 )

• at P7

muscle

decreased ventricle muscle contractility ( J:335098 )

• reduced right ventricular output stroke volume and ejection fraction

Allelic Composition	Bicra^em3Hzhg/Bicra^em3Hzhg Tg(Cdh5-cre)7Mlia/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicra^em3Hzhg mutation (0 available); any Bicra mutation (55 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:335098 )

• mice exhibit normal embryonic survival

cardiovascular system

cardiovascular system phenotype ( J:335098 )

• mice exhibit normal cardiac phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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