About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bicraem3Hzhg
endonuclease-mediated mutation 3, Honghe Zhang
MGI:7488661
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bicraem3Hzhg/Bicraem3Hzhg
Tg(Tnnt2-cre)5Blh/0 		involves: C57BL/6 * DBA/2 MGI:7543773
cn2
 		Bicraem3Hzhg/Bicraem3Hzhg
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:7543774
cn3
 		Bicraem3Hzhg/Bicraem3Hzhg
Tg(Cdh5-cre)7Mlia/0 		involves: FVB/N MGI:7543772


Genotype
MGI:7543773
cn1
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (57 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:335098 )
N
• mice exhibit normal embryonic survival

cardiovascular system
cardiovascular system phenotype ( J:335098 )
N
• mice exhibit normal cardiac phenotype




Genotype
MGI:7543774
cn2
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (57 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
double outlet right ventricle ( J:335098 )
• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum
ventricular septal defect ( J:335098 )
• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum
decreased cardiac output ( J:335098 )
• lower right ventricular output
abnormal coronary circulation ( J:335098 )
• transventricular septal flow
decreased heart right ventricle muscle contractility ( J:335098 )
• reduced right ventricular output stroke volume and ejection fraction

growth/size/body
decreased body size ( J:335098 )
• at P7

muscle
decreased heart right ventricle muscle contractility ( J:335098 )
• reduced right ventricular output stroke volume and ejection fraction




Genotype
MGI:7543772
cn3
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (57 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:335098 )
• mice exhibit normal embryonic survival

cardiovascular system
cardiovascular system phenotype ( J:335098 )
• mice exhibit normal cardiac phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory