All Phenotypes Rr420<tm1.1Itok> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr420^tm1.1Itok
targeted mutation 1.1, Kosei Ito
MGI:7484530

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rr420^tm1.1Itok/Rr420^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:7486534

Allelic Composition	Rr420^tm1.1Itok/Rr420^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr420^tm1.1Itok mutation (0 available); any Rr420 mutation (0 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:319454 )

• survival time is increased compared to mutant mice wild-type for Rr420

neoplasm

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Rr420

• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3^tm1.1Itok

skeleton

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Rr420

• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3^tm1.1Itok

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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