Phenotypes associated with this allele

• Allele Symbol: Rpl3l^em1Kei
• Allele Name: endonuclease-mediated mutation 1, Keiichi I Nakayama
• Allele ID: MGI:7471435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpl3l^em1Kei/Rpl3l^em1Kei	C57BL/6J-Rpl3^em1Kei	MGI:7481239

Genotype
MGI:7481239

hm1

• Allelic Composition: Rpl3l^em1Kei/Rpl3l^em1Kei
• Genetic Background: C57BL/6J-Rpl3^em1Kei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac muscle contractility ( J:335523 )

• left ventricular fractional shortening and ejection fraction are reduced

• the reduced cardiac contractility is not exacerbated by pressure overload-induced by angiotensin II stimulation

• however, mice show no obvious changes in myofiber size or in the extent of cardiac fibrosis

abnormal heart echocardiography feature ( J:335523 )

• echocardiography shows reduced left ventricular fractional shortening and left ventricular ejection fraction, and increased left ventricular end-systolic diameter, while left ventricular wall thickness and end-diastolic diameter are unchanged

growth/size/body

growth/size/body region phenotype ( J:335523 )

N • mice show no difference in body weight at 10 weeks of age or in weight of the heart or skeletal muscle at 18-19 weeks of age

muscle

abnormal cardiac muscle contractility ( J:335523 )

• left ventricular fractional shortening and ejection fraction are reduced

• the reduced cardiac contractility is not exacerbated by pressure overload-induced by angiotensin II stimulation

• however, mice show no obvious changes in myofiber size or in the extent of cardiac fibrosis