Phenotypes associated with this allele

• Allele Symbol: Zranb1^em1Shios
• Allele Name: endonuclease-mediated mutation 1, Shigeru Oshima
• Allele ID: MGI:7449310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zranb1^em1Shios/Zranb1^em1Shios	involves: C57BL/6	MGI:7449347

Genotype
MGI:7449347

hm1

• Allelic Composition: Zranb1^em1Shios/Zranb1^em1Shios
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:333468 )

N • normal colon length and spleen weight

N • no bacterial invasion of colon inner mucus layer or crypts

abnormal colon goblet cell morphology ( J:333468 )

• reduced mucus production

decreased intestinal mucosa thickness ( J:333468 )

• in colon

• reduced mucus production in colon

increased susceptibility to colitis induced morbidity/mortality ( J:333468 )

• increased weight loss and worse clinical and histological scores with DSS-induced colitis

• reduced colon length and increased colon erosion length with DSS-induced colitis

• all mice die by 9 days after 5-day oral administration of 1.5% DSS

cellular

abnormal colon goblet cell morphology ( J:333468 )

• reduced mucus production

growth/size/body

decreased body size ( J:333468 )

• smaller at age 6 weeks

decreased body weight ( J:333468 )

• lower at age 6 weeks

• normal at age 19 weeks

endocrine/exocrine glands

abnormal colon goblet cell morphology ( J:333468 )

• reduced mucus production

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:333468 )

• increased weight loss and worse clinical and histological scores with DSS-induced colitis

• reduced colon length and increased colon erosion length with DSS-induced colitis

• all mice die by 9 days after 5-day oral administration of 1.5% DSS

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:333468 )

• increased weight loss and worse clinical and histological scores with DSS-induced colitis

• reduced colon length and increased colon erosion length with DSS-induced colitis

• all mice die by 9 days after 5-day oral administration of 1.5% DSS

embryo

embryo phenotype ( J:333468 )

N • born at normal Mendelian ratios