Phenotypes associated with this allele

• Allele Symbol: Grin2b^em1Weya
• Allele Name: endonuclease-mediated mutation 1, Wei Yang
• Allele ID: MGI:7449028
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^em1Weya/Grin2b^em1Weya	Not Specified	MGI:7449122

Genotype
MGI:7449122

hm1

• Allelic Composition: Grin2b^em1Weya/Grin2b^em1Weya
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:334279 )

N • normal behavior in sucrose preference test (SPT)

N • normal strength in grip strength test and locomotive activity in open field test (OFT)

N • normal time spent in center in open field test (OFT) and open arms in elevated plus maze

N • normal working memory in Y maze test

N • normal behavior in Morris water maze and contextual fear conditioning tests

N • normal thermal nociception

N • normal amygdala-dependent fear memory

increased coping response ( J:334279 )

• lack of anhedonia in sucrose preference test (SPT) after having been subjected to chronic restraint stress (CRS)

• reduced immobility time in forced swim test (FST) and tail suspension test (TST)

• reduced immobility time in forced swim test (FST) after having been subjected to chronic restraint stress (CRS)

nervous system

nervous system phenotype ( J:334279 )

N • normal gross brain morphology

N • normal long-term potentiation (LPT) in hippocampal slices induced by 100 Hz stimulation train

N • normal amplitude and decay time of NMDA receptor (NMDAR)-mediated excitatory post-synaptic currents (EPSCs) in acute brain slices

N • normal post-synaptic density thickness and length in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons

N • normal miniature inhibitory post-synaptic currents (mIPSCs) amplitude and frequency in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons

N • normal paired-pulse ratio in mPFC layer 5 pyramidal and hippocampus CA1 pyramidal neurons

N • normal NMDAR/AMPAR-EPSCs amplitude ratio in medial prefrontal cortex (mPFC) and hippocampus

increased dendritic spine density ( J:334279 )

• increased apical dendritic spine density in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons, with or without having been subjected to chronic restraint stress (CRS)

• normal in hippocampus pyramidal neurons

abnormal nervous system physiology ( J:334279 )

• reduced NMDA-evoked currents in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons

• no reduction of NMDA-evoked currents in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons after ifenprodil treatment

• normal NMDA-evoked currents in hippocampus CA1 pyramidal neurons

abnormal miniature excitatory postsynaptic currents ( J:334279 )

• increased frequency in medial prefrontal cortex (mPFC) layer 5 pyramidal neurons

• higher frequency in mPFC layer 5 pyramidal neurons after having been subjected to chronic restraint stress (CRS)

• normal amplitude in mPFC layer 5 pyramidal neurons, with or without having been subjected to CRS

• normal in hippocampus pyramidal neurons

growth/size/body

growth/size/body region phenotype ( J:334279 )

N • normal weight