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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr253em6Kmm
endonuclease-mediated mutation 6, Kenneth M Murphy
MGI:7448467
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr253em6Kmm/Rr253em6Kmm C57BL/6J-Rr253em6Kmm MGI:7448524
cx2
 		Irf8em1Kmm/Irf8em1Kmm
Rr253em6Kmm/Rr253em6Kmm 		C57BL/6J-Irf8em1Kmm Rr253em6Kmm MGI:7448526


Genotype
MGI:7448524
hm1
Allelic
Composition		 Rr253em6Kmm/Rr253em6Kmm
Genetic
Background		 C57BL/6J-Rr253em6Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr253em6Kmm mutation (1 available); any Rr253 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:334296 )
N
• normal B cell, eosinophil, neutrophil, group 2 innate lymphoid cell (ILC2) and tuft cell development
• normal common lymphoid progenitors (CLPs) generate plasmacytoid dendritic cells (pDCs) development
• normal B cell response to infection with Heligmosomoides polygyrus (H. polygyrus)
abnormal common myeloid progenitor cell morphology ( J:334296 )
• MCPs dont generate plasmacytoid dendritic cells (pDCs)
decreased granulocyte monocyte progenitor cell number ( J:334296 )
• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow
decreased dendritic cell number ( J:334296 )
• very low bone marrow pre-cDC2s and spleen cCD2 numbers
increased dendritic cell number ( J:334296 )
• increased bone marrow pre-cDC1 and spleen cCD1 numbers
abnormal T-helper 2 physiology ( J:334296 )
• diminished response and IL4, IL5 and IL13 production after infection with H. polygyrus

immune system
immune system phenotype ( J:334296 )
N
• normal B cell, eosinophil, neutrophil, group 2 innate lymphoid cell (ILC2) and tuft cell development
• normal B cell response to infection with Heligmosomoides polygyrus (H. polygyrus)
decreased dendritic cell number ( J:334296 )
• very low bone marrow pre-cDC2s and spleen cCD2 numbers
increased dendritic cell number ( J:334296 )
• increased bone marrow pre-cDC1 and spleen cCD1 numbers
abnormal T-helper 2 physiology ( J:334296 )
• diminished response and IL4, IL5 and IL13 production after infection with H. polygyrus
increased susceptibility to parasitic infection induced morbidity/mortality ( J:334296 )
• failure to form granulomas in small intestine and increased egg burden after infection with Heligmosomoides polygyrus (H. polygyrus)

mortality/aging
increased susceptibility to parasitic infection induced morbidity/mortality ( J:334296 )
• failure to form granulomas in small intestine and increased egg burden after infection with Heligmosomoides polygyrus (H. polygyrus)




Genotype
MGI:7448526
cx2
Allelic
Composition		 Irf8em1Kmm/Irf8em1Kmm
Rr253em6Kmm/Rr253em6Kmm
Genetic
Background		 C57BL/6J-Irf8em1Kmm Rr253em6Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8em1Kmm mutation (1 available); any Irf8 mutation (32 available)
Rr253em6Kmm mutation (1 available); any Rr253 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:334296 )
N
• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)
• normal splenic cDC2 numbers
decreased granulocyte monocyte progenitor cell number ( J:334296 )
• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow
decreased dendritic cell number ( J:334296 )
• bone marrow pre-cDC2s virtually absent
• splenic cDC1s virtually absent
increased dendritic cell number ( J:334296 )
• increase of bone marrow pre-cDC1 numbers

immune system
immune system phenotype ( J:334296 )
N
• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)
• normal splenic cDC2 numbers
decreased dendritic cell number ( J:334296 )
• bone marrow pre-cDC2s virtually absent
• splenic cDC1s virtually absent
increased dendritic cell number ( J:334296 )
• increase of bone marrow pre-cDC1 numbers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory