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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hadhem1Jgao
endonuclease-mediated mutation 1, Jiangang Gao
MGI:7444796
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hadhem1Jgao/Hadhem1Jgao Not Specified MGI:7444811


Genotype
MGI:7444811
hm1
Allelic
Composition		 Hadhem1Jgao/Hadhem1Jgao
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hadhem1Jgao mutation (0 available); any Hadh mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal acrosome morphology ( J:333351 )
• deformed, mislocalized, and missing acrosome
• however, treatment with etanercept improves acrosome development
abnormal male meiosis ( J:333351 )
• partially arrested producing multinucleated giant cells
• however, treatment with etanercept improves male meiosis
increased male germ cell apoptosis ( J:333351 )
• however, treatment with etanercept improves represses germ cell apoptosis
abnormal seminiferous tubule morphology ( J:333351 )
• large vacuoles and disorganized structure
decreased testis weight ( J:333351 )
• however, treatment with etanercept improves testes weight
reduced male fertility ( J:333351 )
• male mice produced reduced litters compared with wild-type mice
• however, treatment with etanercept improves reproductive ability

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:333351 )
• large vacuoles and disorganized structure
decreased testis weight ( J:333351 )
• however, treatment with etanercept improves testes weight

cellular
abnormal acrosome morphology ( J:333351 )
• deformed, mislocalized, and missing acrosome
• however, treatment with etanercept improves acrosome development
abnormal male meiosis ( J:333351 )
• partially arrested producing multinucleated giant cells
• however, treatment with etanercept improves male meiosis
increased male germ cell apoptosis ( J:333351 )
• however, treatment with etanercept improves represses germ cell apoptosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory