Phenotypes associated with this allele

• Allele Symbol: Inka2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:7442114
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inka2^tm1b(KOMP)Wtsi/Inka2^tm1b(KOMP)Wtsi	involves: C57BL * C57BL/6 * DBA	MGI:7442133

Genotype
MGI:7442133

hm1

• Allelic Composition: Inka2^{tm1b(KOMP)Wtsi}/Inka2^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:330575 )

N • mice exhibit normal lateral ventricles, corpus callosum thickness, and cortical neuron numbers

abnormal dendrite arborization pattern ( J:330575 )

• spines have globular-shaped head and think necks that connects the head to the shaft of the dendrite

abnormal dendritic spine morphology ( J:330575 )

• abnormal apical dendrites with thinner, irregularly distorted, and wavy morphology

• dendritic spines are smaller and have irregularly distorted heads

• impaired dendritic spine formation

decreased dendritic spine number ( J:330575 )

• in 1-month-old and 6-month-old mice

abnormal pyramidal neuron dendrite morphology ( J:330575 )

• lost or invisible thick apical dendrites in layer V pyramidal neurons of the neocortices

• apical and basal dendrites exhibit abnormal bending compared with wild-type neurons

• decreased number of dendritic spines