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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr387em1Zyliu
endonuclease-mediated mutation 1, Zhiyong Liu
MGI:7440065
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr387em1Zyliu/Rr387em1Zyliu Not Specified MGI:7447203
cx2
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu 		Not Specified MGI:7447205
cx3
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu 		Not Specified MGI:7447206
cx4
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu 		Not Specified MGI:7447208


Genotype
MGI:7447203
hm1
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal vestibular hair cell development

mortality/aging
premature death ( J:333396 )
• mice die around age P35

nervous system
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447205
cx2
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear length at age P1
decreased cochlear outer hair cell number ( J:333396 )
• 93% lower density in all turns at age P1 and 98% at age P30

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable
premature death ( J:333396 )
• mice die around age P35

nervous system
decreased cochlear outer hair cell number ( J:333396 )
• 93% lower density in all turns at age P1 and 98% at age P30
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447206
cx3
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear hair cell development
• normal cochlear length at age P1

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable
premature death ( J:333396 )
• mice die around age P35

nervous system
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447208
cx4
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear length at age P1
decreased cochlear hair cell number ( J:333396 )
• 97% lower density in all turns at age P1

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable

nervous system
decreased cochlear hair cell number ( J:333396 )
• 97% lower density in all turns at age P1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory