About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr387em1Zyliu
endonuclease-mediated mutation 1, Zhiyong Liu
MGI:7440065
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr387em1Zyliu/Rr387em1Zyliu Not Specified MGI:7447203
cx2
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu 		Not Specified MGI:7447205
cx3
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu 		Not Specified MGI:7447206
cx4
 		Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu 		Not Specified MGI:7447208


Genotype
MGI:7447203
hm1
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal vestibular hair cell development

mortality/aging
premature death ( J:333396 )
• mice die around age P35

nervous system
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447205
cx2
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear length at age P1
decreased cochlear outer hair cell number ( J:333396 )
• 93% lower density in all turns at age P1 and 98% at age P30

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable
premature death ( J:333396 )
• mice die around age P35

nervous system
decreased cochlear outer hair cell number ( J:333396 )
• 93% lower density in all turns at age P1 and 98% at age P30
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447206
cx3
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear hair cell development
• normal cochlear length at age P1

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable
premature death ( J:333396 )
• mice die around age P35

nervous system
abnormal cerebellum development ( J:333396 )
• abnormal morphology at age P30




Genotype
MGI:7447208
cx4
Allelic
Composition		 Rr387em1Zyliu/Rr387em1Zyliu
Rr388em1Zyliu/Rr388em1Zyliu
Rr397em1Zyliu/Rr397em1Zyliu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:333396 )
N
• normal cochlear length at age P1
decreased cochlear hair cell number ( J:333396 )
• 97% lower density in all turns at age P1

embryo
embryo phenotype ( J:333396 )
N
• viable

mortality/aging
mortality/aging ( J:333396 )
N
• viable

nervous system
decreased cochlear hair cell number ( J:333396 )
• 97% lower density in all turns at age P1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory