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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zmynd8em1Lwb
endonuclease-mediated mutation 1, Weibo Luo
MGI:7431277
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-PyVT)634Mul/0
Tg(KRT14-cre)1Amc/0 		involves: C57BL/6N * CBA * FVB MGI:7432306
cn2
 		Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-cre)4Mam/0
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6N * FVB MGI:7432304


Genotype
MGI:7432306
cn1
Allelic
Composition		 Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-PyVT)634Mul/0
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: C57BL/6N * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Zmynd8em1Lwb mutation (0 available); any Zmynd8 mutation (506 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

integument
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

neoplasm
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice




Genotype
MGI:7432304
cn2
Allelic
Composition		 Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-cre)4Mam/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)4Mam mutation (2 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Zmynd8em1Lwb mutation (0 available); any Zmynd8 mutation (506 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

integument
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory