Phenotypes associated with this allele

• Allele Symbol: Zfp14^tm1Xch
• Allele Name: targeted mutation 1, Xinbin Chen
• Allele ID: MGI:7429175
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp14^tm1Xch/Zfp14^tm1Xch	involves: C57BL/6	MGI:7429195
ht2	Zfp14^tm1Xch/Zfp14^+	involves: C57BL/6	MGI:7429197

Genotype
MGI:7429195

hm1

• Allelic Composition: Zfp14^tm1Xch/Zfp14^tm1Xch
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

thymus hyperplasia ( J:331393 )

chronic pancreas inflammation ( J:331393 )

• increased susceptibility to pancreatitis

growth/size/body

spleen hyperplasia ( J:331393 )

hematopoietic system

thymus hyperplasia ( J:331393 )

spleen hyperplasia ( J:331393 )

immune system

thymus hyperplasia ( J:331393 )

spleen hyperplasia ( J:331393 )

lymph node hyperplasia ( J:331393 )

increased inflammatory response ( J:331393 )

• increased inflammation in liver, lung, kidney, salivary gland and other organs and tissues

• chronic inflammation in more than 3 organs in 94% of mice

• chronic inflammation in more than 4 organs in 82% of mice

chronic pancreas inflammation ( J:331393 )

• increased susceptibility to pancreatitis

integument

skin hyperplasia ( J:331393 )

liver/biliary system

hepatic steatosis ( J:331393 )

mortality/aging

premature death ( J:331393 )

• 80 weeks median lifespan vs 117 for WT

neoplasm

increased tumor incidence ( J:331393 )

• 47% spontaneous tumor penetrance vs 22% for WT

increased B cell derived lymphoma incidence ( J:331393 )

• increased incidence of diffuse large B cell lymphomas (DLBCL)

Genotype
MGI:7429197

ht2

• Allelic Composition: Zfp14^tm1Xch/Zfp14⁺
• Genetic Background: involves: C57BL/6

endocrine/exocrine glands

thymus hyperplasia ( J:331393 )

chronic pancreas inflammation ( J:331393 )

• increased susceptibility to pancreatitis

growth/size/body

spleen hyperplasia ( J:331393 )

hematopoietic system

thymus hyperplasia ( J:331393 )

spleen hyperplasia ( J:331393 )

immune system

thymus hyperplasia ( J:331393 )

spleen hyperplasia ( J:331393 )

lymph node hyperplasia ( J:331393 )

increased inflammatory response ( J:331393 )

• increased inflammation in liver, lung, kidney, salivary gland and other organs and tissues

• chronic inflammation in more than 3 organs in 90% of mice

• chronic inflammation in more than 4 organs in 47% of mice

chronic pancreas inflammation ( J:331393 )

• increased susceptibility to pancreatitis

integument

skin hyperplasia ( J:331393 )

liver/biliary system

hepatic steatosis ( J:331393 )

mortality/aging

premature death ( J:331393 )

• 87 weeks median lifespan vs 117 for WT

neoplasm

increased tumor incidence ( J:331393 )

• 43% spontaneous tumor penetrance vs 22% for WT

increased B cell derived lymphoma incidence ( J:331393 )

• increased incidence of diffuse large B cell lymphomas (DLBCL)