Zfp14^tm1Xch
Targeted Allele Detail

Summary

• Symbol: Zfp14^tm1Xch
• Name: zinc finger protein 14; targeted mutation 1, Xinbin Chen
• MGI ID: MGI:7429175
• Synonyms: Zfp14^-
• Gene: Zfp14 Location: Chr7:29735784-29750805 bp, - strand Genetic Position: Chr7, 17.26 cM
• Alliance: Zfp14^tm1Xch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The following were inserted into intron 5 (after the second coding exon): an FRT site, En2 splice acceptor sequence, an IRES, the lacZ beta-galactosidase gene, poly(A) signal sequence, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site. A third loxP site was inserted downstream of the gene after exon 6. This creates a knockout allele. (J:331393)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Zfp14^tm1Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp14 Mutation: 21 strains or lines available

References

• Original: J:331393 Mohibi S, et al., Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster. Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166587
• All: 1 reference(s)