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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hhatem1(IMPC)Ccpcz
endonuclease-mediated mutation 1, Institute of Molecular Genetics
MGI:7425740
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		\Hhatem1(IMPC)Ccpcz/\Hhatem1(IMPC)Ccpcz C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz MGI:7768351
ht2
 		\Hhatem1(IMPC)Ccpcz/\Hhat+ C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz MGI:7768350


Genotype
MGI:7768351
hm1
Allelic
Composition		 \Hhatem1(IMPC)Ccpcz/\Hhatem1(IMPC)Ccpcz
Genetic
Background		 C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhatem1(IMPC)Ccpcz mutation (1 available); any Hhat mutation (27 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal head shape ( J:211773 )
IMPC - CCP-IMG

embryo

growth/size/body
abnormal facial morphology ( J:211773 )
IMPC - CCP-IMG
abnormal head shape ( J:211773 )
IMPC - CCP-IMG
abnormal outer ear morphology ( J:211773 )
IMPC - CCP-IMG
abnormal head size ( J:211773 )
IMPC - CCP-IMG

hearing/vestibular/ear

homeostasis/metabolism
edema ( J:211773 )
IMPC - CCP-IMG

limbs/digits/tail
syndactyly ( J:211773 )
IMPC - CCP-IMG

mortality/aging

nervous system
holoprosencephaly ( J:211773 )
IMPC - CCP-IMG

vision/eye
anophthalmia ( J:211773 )
IMPC - CCP-IMG




Genotype
MGI:7768350
ht2
Allelic
Composition		 \Hhatem1(IMPC)Ccpcz/\Hhat+
Genetic
Background		 C57BL/6NCrl-Hhatem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hhatem1(IMPC)Ccpcz mutation (1 available); any Hhat mutation (27 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged thymus ( J:211773 )
IMPC - CCP-IMG

growth/size/body
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

hematopoietic system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

immune system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory