Phenotypes associated with this allele

• Allele Symbol: Mphosph8^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7423697
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr Mphosph8^tm1c(EUCOMM)Wtsi/Mphosph8^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6N * SJL	MGI:7424798
cn2	Mphosph8^tm1c(EUCOMM)Wtsi/Mphosph8^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: C57BL/6N * SJL	MGI:7424789

Genotype
MGI:7424798

cn1

• Allelic Composition: Morc2a^tm1.1Pngr/Morc2a^tm1.1Pngr; Mphosph8^{tm1c(EUCOMM)Wtsi}/Mphosph8^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:332344 )

• more so than in either single conditional knock-out mouse

nervous system

increased brain size ( J:332344 )

• increased brain to body ratio

abnormal corpora quadrigemina morphology ( J:332344 )

• exposed colliculi

craniofacial

domed cranium ( J:332344 )

growth/size/body

decreased body weight ( J:332344 )

skeleton

domed cranium ( J:332344 )

Genotype
MGI:7424789

cn2

• Allelic Composition: Mphosph8^{tm1c(EUCOMM)Wtsi}/Mphosph8^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6N * SJL

mortality/aging

premature death ( J:332344 )

• more so than in either single conditional knock-out mouse

nervous system

increased brain size ( J:332344 )

• increased brain to body ratio

abnormal corpora quadrigemina morphology ( J:332344 )

• exposed colliculi

craniofacial

domed cranium ( J:332344 )

growth/size/body

decreased body weight ( J:332344 )

skeleton

domed cranium ( J:332344 )